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Hot New Products Aminoguanidine Hydrochloride Usp - Aminoguanidine Hydrochloride – Hailun New Material

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Hot New Products Aminoguanidine Hydrochloride Usp - Aminoguanidine Hydrochloride – Hailun New Material Detail:

Product name:carbazamidine hydrochloride; (diaminomethylidene)hydrazinium chloride
Molecular Formula:CH6N4HCL
CAS1937-19-5
Molecular Weight:110.55
Structural Formula:

yy1

 

Use:Pharmaceutical, veterinary drugs

Index name

Index Value

Appearance

White like crystalline powder

Content

98%

99%

Insoluble Substances

0.2%

0.1%

Loss on Drying

1.5%

1%

Ignition Residue

0.2%

0.1%

Iron Content(Fe)

10 ppm

6 ppm

Free Acid

0.8%

0.5%

preparation

Preparation of aminoguanidine hydrochloride: 9 g of aminoguanidine carbonate was put into a 250ml three port flask, 20ml of absolute ethanol was added, the solid was insoluble in anhydrous ethanol to form a suspension. Under stirring at room temperature, the mixture of 6ml 30% concentrated hydrochloric acid and 10ml of absolute ethanol was dropwise added until there was no bubble, and then stirring reaction was continued at room temperature for 1 hour. The obtained suspension was heated to dissolve the solid completely, and then it was naturally lowered to room temperature. After being moved to the refrigerator and placed overnight, the white rod-shaped crystal with melting point of 166-167 was obtained.

Application

Daidzein has a variety of pharmacological effects, prevention and treatment of a variety of diseases. Cn200910144204.1 reported that aminoguanidine hydrochloride can be used to prepare a chemically modified daidzein, namely, daidzein 7,4 ‘- oxy aminoguanidine acetate. The soybean aglycone 7,4 ‘- oxy aminoguanidine acetate is a prodrug compound, which releases the parent drug – daidzein under physiological conditions, and improves its water solubility by covalent binding.

The preparation of Daidzein 7,4 - o-aminoguanidine acetate: 0.5g aminoguanidine hydrochloride was dissolved in 100ml acetone, 0.02g phase transfer catalyst, 0.5g anhydrous potassium carbonate, 0.5g 7,4 - chloroacetyl daidzein and 0.02g I2 were added into the solution. The reaction was carried out at room temperature for 24 hours. Acetone was evaporated from the filtrate under reduced pressure, and then separated by silica gel column. The eluent was ethyl acetate petroleum ether When the ratio is 1 2, the white powder solid is obtained.

 

 


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We've one of the most advanced generation tools, experienced and qualified engineers and workers, recognized good quality manage systems and a friendly skilled product sales workforce pre/after-sales support for Hot New Products Aminoguanidine Hydrochloride Usp - Aminoguanidine Hydrochloride – Hailun New Material , The product will supply to all over the world, such as: Mecca, Cairo, Madagascar, We are your reliable partner in the international markets of our products. We focus on providing service for our clients as a key element in strengthening our long-term relationships. The continual availability of high grade products in combination with our excellent pre- and after-sales service ensures strong competitiveness in an increasingly globalized market. We are willing to cooperate with business friends from at home and abroad, to create a great future. Welcome to Visit our factory. Looking forward to have win-win cooperation with you.
  • We have been engaged in this industry for many years, we appreciate the work attitude and production capacity of the company, this is a reputable and professional manufacturer.
    5 Stars By Riva from Peru - 2018.12.11 14:13
    We have been engaged in this industry for many years, we appreciate the work attitude and production capacity of the company, this is a reputable and professional manufacturer.
    5 Stars By Tyler Larson from Mombasa - 2018.05.15 10:52
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